| Background |
Noggin binds members of the transforming Growth Factors-beta (TGF beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP-4), which inactivates their activities. As a extracellular antagonist of BMP proteins, Noggin involves in the development of many body tissues, including nerve tissue, muscles, and bones. In addition, Noggin is able to inhibit chondrocyte differentiation through its interaction with GDF5. |
| Synonyms |
Nog |
| Uniprot ID |
P97466 |
| Molecular Weight |
The protein has a calculated MW of 49.14 kDa.
The protein migrates as 50 kDa under reducing condition (SDS-PAGE analysis). |
| Expression System |
HEK293 cell |
| Purity |
>95% as determined by SDS-PAGE. |
| Activity |
Testing in process |
| Endotoxin Level |
<0.1 EU per 1 μg of the protein by the LAL method. |
| Protein Sequence |
A DNA sequence encoding Mouse Noggin(#P97466) (Met1-Cys232) was expressed with Human IgG1 Fc tag at the C-terminus. |
| Protein Tag |
Human IgG1 Fc Tag (C-term) |
| Form |
The protein was lyophilized from a 0.2 µm filtered solution containing 1X PBS, pH 7.4. If you have any concerns or special requirements, please confirm with us. |
| Application |
Cell Culture |
No references are available
